【摘要】 目的探讨左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、B型钠尿肽(BNP)、肿瘤坏死因子-α(TNF-α)、胱抑素C(CysC)与扩张型心肌病(DCM)患者心脏再同步化治疗(CRT)后发生室性快速性心律失常的关系。方法选择济宁市第一人民医院行CRT的DCM患者36例,术前行超声心动图检查,静脉血检测BNP、TNF-α、CysC水平;术后随访1年,CRT起搏器记录随访期间持续性室性心动过速(VT)、心室颤动(VF)的发生次数并经程控仪分析。结果共完成随访34例,其中无事件组23例(67.65%),VT/VF组11例(32.35%);两组相比较,仅LVEDD差异有统计学意义(P<0.05),BNP、LVEF、TNF-α、CysC差异均无统计学意义(P>0.05)。结论 LVEDD是DCM患者CRT治疗后发生室性快速性心律失常准确的预测因子,没有发现BNP、LVEF、TNF-α、CysC与此有关。更多还原

【Abstract】 Objective To investigate the relationship between the left ventricular diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),plasma levels of BNP,TNF-α,Cystatin C(CysC) and ventricular tachyarrhythmia after cardiac resynchronization therapy(CRT)in patients with dilated cardiomyopathy( DCM). Methods Thirty-six patients with DCM underwent CRT in our hospital were chose,and the levels of BNP,TNF-α and CysC were detected. The patients were followed-up for one year,during which the number of consistent ventricular tachycardia(VT) and ventricular fibrillation(VF) were recorded by the CRT pacemaker and analyzed by program recording control instrument. Results Follow-up data were obtained from 34 patients,among them,23 patients(67. 65%) had no events,11 patients(32. 35%) had VT or VF. LVEDD level in VT / VF group was significantly higher than that in the no events group,there were significant differences(P < 0. 05). There were no significant differences in the levels of BNP,TNF-α,CysC or LVEF( P > 0. 05). Conclusion LVEDD is an accurate predicting factor for ventricular tachyarrhythmia after CRT in patients with DCM. LVEF and plasma levels of BNP,LVEF,TNF-α,CysC were not correlated with ventricular tachyarrhythmia after CRT in patients with DCM.更多还原