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温阳复方对高脂高糖饮食诱导的肥胖大鼠血脂的影响

Effects of Warming-Yang Compound Chinese Traditional Medicine on Seral Lipids in High Fat and Sugar Diet-induced Obese Rats

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【作者】 刘华桢谢芳一吴凤玲梁楚燕侯少贞蒋东旭陈长青

【Author】 LIU Hua-zhen;XIE Fang-yi;WU Feng-ling;LIANG Chu-yan;HOU Shao-zhen;JIANG Dong-xu;CHEN Chang-qing;Guangzhou University of Chinese Medicine;Hunan Academy of Chinese Medicine;Dongguan Mathematical Engineering Institute of Chinese Medicine;

【机构】 广州中医药大学湖南省中医研究院东莞广州中医药大学中医药数理工程研究院

【摘要】 为研究温阳为主中药复方对肥胖大鼠体重和血脂的影响,探讨温阳法治疗肥胖的可行性,本试验取SD肥胖大鼠成5组,分别为模型组、阳性药二甲双胍组、温阳复方组、温阳药对组、阴性复方组,每天灌胃给药1次,给药8周下腔静脉取血测定相关指标。结果表明,温阳复方能有效降低肥胖大鼠的TG、TC、LDL,并升高HDL(P<0.05)。说明温阳中药复方具有能够减轻体重、调整脂代谢的作用。

【Abstract】 To study the effect of Warming-Yang compound Chinese traditional medicine(WY-CCTM)on decreasing of serum lipids and body mass index in obese rats,obese rats were divided into 5groups,model control,metformin-treated group,WY-CCTM-treated group,Warming-Yang herb-partners-treated group and negative-CCTM-treated group.All the rats were administrated once a day for 8weeks.At the end of the study,rats were all scarified and blood samples were got to determine the serum levels of TG,TC,LDL and HDL.The results shoued that WY-CCTM could reduce TG,TC,LDL levels and increase HDL levels in obese rats significantly,compared with the model control group.WY-CCTM could reduce body weight,regulate lipid metabolism in obese rats.

【关键词】 肥胖大鼠温阳复方脂代谢
【Key words】 obese ratWarming-Yang compoundlipid metabolism
【基金】 广东省科技计划项目(2011A030100016);广东省科技计划项目(2011B031700070)
  • 【文献出处】 动物医学进展 ,Progress in Veterinary Medicine , 编辑部邮箱 ,2014年04期
  • 【分类号】S853.7
  • 【被引频次】9
  • 【下载频次】143
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