Radiographic detection of pulmonary nodules based on three-dimensional Hessian matrix is highly sensitive but frequently produces false positive results in areas where blood vessels intersect.We propose a novel approach to pulmonary nodule detection using Hessian matrix-based adaptive window structure analysis,in which the structure coefficients is used to differentiate a voxel that belongs to a nodule or vascular structures,followed by construction of the 3D adaptive window to analyze the local structure c...