【摘要】 目的:分析药物超敏反应综合征的药物流行病学特征,提高对药物超敏反应综合征特殊性的认识。方法:对近4年来在院诊治的药物超敏反应综合征进行回顾性病例分析总结。结果:28例患者中,怀疑药物为别嘌醇的有17例,抗癫痫药有4例,抗结核药3例,非甾体抗炎药4例。大多以皮疹(89.3%)或发热(85.7%)为首发症状,其次可出现肝功能损害(75%),可伴黏膜、眼、生殖器损害(53.6%),嗜酸粒细胞明显增高(32.1%),肾功能损害(17.9%)等,甚至出现多脏器功能衰竭、死亡(7.1%)。结论:如患者出现皮疹、反复高热、内脏损害等,经普通抗过敏或抗感染治疗效果不佳并且有以上几类药物用药史,应高度警惕药物超敏反应综合征。更多还原

【Abstract】 Objective: To investigate the pharmacoepidemiologic features of drug-induced hypersensitivity syndrome(DHS) and improve the recognition of its particularity.Methods:DHS diagnosed in our hospital in recent 4 years were retrospectively analyzed and summarized.Results:Of 28 cases of DHS the suspected drugs were allopurinol in 17 cases, anti-epileptic drugs in 4 cases, antiuberculotic drugs in 3 cases and antiuberculotic drugs in 4 cases.The earliest symptoms of DHS were skin rash(96.4%) and fever(70%), secondly liver function damaged(50%), which may be accompanied by mucosa, eye, genital damage(50%), eosinophilia(40%), renal impairmen(40%), even Multiple organ failure and death.Conclusion:DHS should be on the alert when rash, repeatedly fever and visceral lesion occurred in a patient, without good therapeutic efficacy through ordinary anti-anaphylaxis and anti-infective therapy as well as with the above medication history.更多还原