BiPAP通气联合布地奈德/福莫特罗治疗COPD疗效观察

【摘要】 目的探讨布地奈德/福莫特罗(信必可)联合双水平气道正压(BiPAP)通气对中度以上慢性阻塞性肺疾病(COPD)的肺功能和生活质量的影响。方法将COPD稳定期患者90例,随机分为3组。A组30例,单一使用信必可;B组30例,单一使用BiPAP通气;C组30例,联合使用信必可和BiPAP通气。治疗前和治疗后3个月测定患者肺功能和6min行走距离(6-MWD),统计第1s用力呼气容积(FEV1)占预计值%、FEV1/用力肺活量(FVC)%,比较各组治疗前后的改善率。结果 BiPAP通气加信必可与单一采用BiPAP通气或信必可比较,对FEV1占预计值%、FEV1/FVC%的改善率及6-MWD的改善率的差异均有统计学意义(P<0.01)。结论对COPD稳定期患者采用BiPAP通气加信必可治疗,其效果比单一采用BiPAP通气或信必可治疗,更能改善肺功能、提高生活质量,值得推广。更多还原

【Abstract】 Objective To study the influence of combination therapy of bi-level positive airway pressure(BiPAP) ventilation and inhaling budesonide/formoterol on lung function and quality of life to patients with moderate or severe chronic obstructive pulmonary disease(COPD) in stabilization period. Methods 90 cases with moderate or severe COPD in stabilization period were randomly divided into A, B and C group. A group: 30 cases were treated with inhaling budesonide/formoterol. B group: 30 cases were treated with BiPAP ventilation. C group: 30 cases were treated with combination therapy of BiPAP ventilation and inhaling budesonide/formoterol. To compare the improvement of index of 3 groups, the lung function and walking distance of 6 minutes(6-MWD) were measured before and after the treatment. Results Compared with A group and B group, the lung function and 6-MWD of C group had obviously been improved, the difference was significant(P<0.01). Conclusion The effect of combination therapy of BiPAP ventilation and inhaling budesonide/formoterol to the patients with COPD in stabilization period was prior to the effect of treated with budesonide/formoterol or BiPAP ventilation singly. The technique was worthy to be widely used.更多还原