【摘要】 目的观察中药糖通饮方对早期糖尿病肾病患者血清血管内皮生长因子(VEGF)的影响。方法将80例患者随机分为对照组40例,治疗组40例,对照组予以常规治疗,治疗组在对照组治疗基础上加用中药糖通饮方(药用黄芪、地骨皮、熟地黄、山药等)治疗,治疗12周,检测治疗前后患者VEGF、空腹血糖(FBG)、餐后2 h血糖(2Hbg)、尿素氮(BUN)及肌酐(Scr),计算内生肌酐清除率(Ccr)等指标。结果治疗后,治疗组较对照组VEGF、FBG、2hBG、Scr显著下降,Ccr显著升高(P<0.05或P<0.01)。结论中药糖通饮方治疗早期糖尿病肾病能改善患者肾功能,降低VEGF,对肾脏病变具有保护作用。更多还原

【Abstract】 Objective To observe the effectof the Chinese herb Tangtong Yin(TTY)onVEGF in patientswith early stage of diabetic nephropathy.Methods 80 patientswere randomly divided into two groups:control group(n= 40)and treatment group(n= 40).The control group was given conventional treatment.The treatment group was added Tangtong Yin(Astragalus,Lycium chinense,prepared rhizome of rehmannia,Chinese yam,etc.)besides the conventional treatment.The patients received 12-week treatment.VEGF、FBG、2Hbg、Bun、Ccr、Scr and other indicatorswere detected before and after the treatment.Results VEGF、FBG、2Hbg and Scrof the treatmentgroupwere distinctly decreased comparedwith those of the control group,the Ccr and INS were distinctly increased compared with those of the control group(P< 0.05 or P< 0.001). Conclusion TTYfor patientswith early stage of diabetic nephropathy can improve the renal function,decrease VEGF and has a protective effect on renal lesions.更多还原