【摘要】 以二氧六环/水为溶剂体系,以聚己内酯(PCL)和聚乙烯吡咯烷酮(PVP)为原料,采用相分离法制备纳米纤维支架,研究了陈化、溶剂比例和PVP含量对支架的纳米纤维结构形成的影响,以及PVP的添加对支架生物活性和亲水性能的影响。结果表明,陈化直接影响纳米纤维网络结构的形成;溶剂体系和PVP含量均影响纳米纤维结构,随着PVP含量的提高纳米纤维结构逐渐消失。随着PVP含量的提高,支架的亲水性能提高。PVP/PCL复合纳米纤维支架浸泡模拟体液(SBF)后在其内部和表面皆生成碳磷灰石(CHA)涂层,表明该纳米纤维支架具有良好的生物活性,且PVP/PCL支架比纯PCL支架能更快诱导生成碳磷灰石。更多还原

【Abstract】 By using polycarpolactone(PCL) and polyvinylpyrrolidone(PVP) as raw materials, a series of nanofibrous scaffolds were fabricated by thermally induced phase separation in a dioxane/water system. The effect of aging temperature, PVP content and different ratios of dioxane to water on the morphology of nanofibrous scaffolds was investigated. The effect of PVP content on the biological activity and hydrophilic performance of the prepared nanofibrous scaffolds were also examined. The results show that aging process played a crucial role in forming the unique nanofibrous structure. The solvent system and the PVP content affect the nanofibrous structure, peculiarly; the nanofibrous structure would disappear gradually with the increasing PVP content. The result of the water absorption shows that the hydrophilic performance of the nanofibrous stent increases with the increasing PVP content. Furthermore, the test of biological activity shows that there exists crystallite carbonate hydroxyapatite in the scaffolds, indicating that the PCL/PVP nanofiberous scaffolds have a good biological activity, and which may much rapidly facilitate the forming of crystallite carbonate hydroxyapatite rather than the merely PCL ones.更多还原