【摘要】 目的:探讨酒精性肝硬化病人能量代谢和临床特点。方法:设酒精性肝硬化病人为研究组(酒精组),乙肝肝硬化病人为对照组(乙肝组),每组各30例。根据肝功能进行Child-Pugh分级,应用Med Graphic CCM/D营养代谢测试系统进行能量代谢测定。结果:两组病人实测静息能量消耗(REE)与REE预计值的比值均<90%。酒精组病人的呼吸商(RQ)低于乙肝组,脂肪氧化率(FAT)%高于乙肝组,蛋白质氧化率(PRO)%低于乙肝组,差异均有统计学意义(P<0.01)。随着Child-Pugh分级由A级至C级,FAT%和PRO%逐渐升高,两组均伴随糖类氧化率(CHO)%和RQ值逐渐降低。相同Child-Pugh分级,酒精组FAT%高于乙肝组,而PRO%却低于乙肝组。结论:酒精性肝硬化病人为低代谢状态,代谢率随肝功能Child-Pugh分级发生动态变化。其突出表现为:1RQ值降低更明显;2糖利用障碍;3能量和物质代谢异常随Child-Pugh由A级至C级更突出。更多还原

【Abstract】 Objective: To investigate the energy metabolism and clinical features in patients with alcoholic cirrhosis. Methods: 60 patients were divided into two groups,30 cases of alcoholic cirrhosis as the study group(alcohol group),30 cases of hepatitis B liver cirrhosis patients as the control group(hepatitis B group). Indirect calorimetry was applied to detect the indexes of energy metabolism for two groups. Results: The ratios of measured REE and predict REE were < 90% in two groups. RQ values and PRO% in alcohol group were lower than that of hepatitis B group,but FAT% was higher,and the difference was statistically significant(P < 0. 01). With Child-Pugh A to C,FAT% and PRO% gradually increased in both groups,and CHO% and RQ values decreased. In the alcohol group,FAT% was higher than that in the hepatitis B group,while PRO% was lower than that in the hepatitis B group.Conclusion: Alcoholic cirrhosis is of low metabolic state. RQ value decreases,fat is the main material for energy,and the metabolism abnormalities is prominent.更多还原