【摘要】 目的观察肺结核合并糖尿病患者血清IL-2、TNF-α的表达,并初步探讨其临床意义。方法试验分为对照组(门诊健康体检者,n=10)、肺结核组(n=20)、糖尿病组(n=20)和肺结核合并糖尿病组(n=20),治疗2个月后根据病情转归将肺结核合并糖尿病组分为好转组及恶化组,ELISA法检测血清中IL-2、TNF-α水平。结果治疗前:肺结核组、糖尿病组、肺结核合并糖尿病组血清IL-2水平均降低(P<0.05),其中肺结核合并糖尿病组低于肺结核组和糖尿病组(P<0.05);肺结核合并糖尿病组、肺结核组、糖尿病组血清TNF-α水平均升高(P<0.05),其中肺结核合并糖尿病组高于糖尿病组(P<0.05);治疗后:肺结核合并糖尿病好转组血清IL-2水平上升,而TNF-α水平有明显下降(P<0.05),恶化组治疗前后变化不明显(P>0.05)。结论IL-2、TNF-α在肺结核合并糖尿病的免疫发病机制中起着一定的作用,其动态变化能反应肺结核合并糖尿病的病情发展及转归。更多还原

【Abstract】 Objective To investigate the expression of serum interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)in the patients with pulmonary tuberculosis and diabetes,and prelininary explore its clinical significance.Methods Experiment were divided into control group(health check-up outpatient,n=10),pulmonary tuberculosis group(n=20),diabetes group(n=20),tuberculosis combine diabetes group(n=20),tuberculosis combine diabetes group was divided into improved group,diabetes group and deteriorated group after 2months with therapy according to disease outcome,ELISA assay was used to measured the level of serum IL-2and TNF-α.Results Before treatment:serum IL-2levels of pulmonary tuberculosis group,diabetes group and pulmonary tuberculosis combine diabetes group were reduced(P<0.05),and the pulmonary tuberculosis group was lower than the pulmonary tuberculosis group and diabetes group(P<0.05);serum TNF-αlevels of pulmonary tuberculosis combine diabetes group,pulmonary tuberculosis group and diabetes group increased(P<0.05),and that of pulmonary tuberculosis combine diabetes group was higher than that of diabetes group(P<0.05).After treatment:the level of serum IL-2increased and TNF-αsignificantly decreased in pulmonary tuberculosis combine diabetes improved group(P<0.05),the deterioration group had no change(P>0.05).ConclusionIL-2and TNF-αplay a role in the immune pathogenesis of tuberculosis combine diabetes,which dynamic changes can reflect the progression and outcome of pulmonary tuberculosis combine diabetes.更多还原