【摘要】 目的探讨2型糖尿病(T2DM)患者血清中内脂素、瘦素及其他指标的表达水平、相关关系及临床意义。方法选取性别和年龄匹配的T2DM患者82例(T2DM组)和健康者71例(健康对照组),测定其血清内脂素、瘦素、胰岛素及血脂、血糖水平。结果 T2DM组的内脂素、瘦素、血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)、稳态胰岛素抵抗指数(HOMA-IR)、2hFPG、2hFINS与健康对照组比较,差异有统计学意义(P<0.05)。相关性分析显示,T2DM组中内脂素与体质量指数(BMI)、FINS、HOMA-IR、TC、TG、LDL-C均呈正相关(P<0.05),与HDL-C成负相关(P<0.05);瘦素与BMI、FINS、HOMA-IR成正相关(P<0.05)。结论 T2DM患者血清中内脂素及瘦素的表达水平高于健康者,与血脂、血糖及胰岛素密切相关,可能成为T2DM新的诊断指标。更多还原

【Abstract】 Objective To investigate the expression levels of serum visfatin,leptin and other indexes and their correlation and clinical significance in the patients with type 2diabetes mellitus(T2DM).Methods Eighty-two age-matched and gender-matched cases of T2DM(T2DM group)and 71 cases of healthy subjects(health control group)were tested serum visfatin,leptin,insulin,lipid and glycemia levels.Results The serum visfatin,leptin,triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDC-C),fasting plasma glucose,fasting insulin(FINS),homeostasis model assessment of insulin resistance(OMA-IR),2hFPG,2hFINS had statistically significant differences between the T2 DM group and the health control group(P<0.05);the stepwise regression analysis showed that visfatin were positively correlated with BMI,FINS,HOMA-IR,TC,TG,LDL-C(P<0.05)and negatively correlated with HDL-C(P<0.05);leptin were positively correlated with BMI,FINS,HOMA-IR(P<0.05).Conclusion Serum visfatin and leptin in the T2 DM patients are hither than those in the healthy subjects and closely related with blood lipid,blood glucose and insulin,which may become the new diagnostic indexes of T2 DM.更多还原