【摘要】 目的观察磷酸川穹嗪对老年颅内动脉瘤夹闭术后早期脑缺血(ECI)患者血液动力学的影响及其预后情况,探讨其临床应用的治疗价值。方法将43例老年颅内动脉瘤夹闭术后ECI患者随机分为两组,川穹嗪组20例,常规组23例。川穹嗪组给予传统治疗联合静脉滴注川穹嗪;常规组仅予传统治疗。采用格拉斯哥预后(GOS)评分、中国卒中量表(CSS)进行预后评分。结果川穹嗪对ECI的临床治疗有效率显著高于传统治疗方式(P<0.05)。常规组ECI患者恢复良好7例(30.43%),轻度残疾8例(34.78%),重度残疾4例(17.39%),植物生存1例(4.34%),死亡3例(13.06%);川穹嗪组恢复良好12例(60.00%),轻度残疾5例(25.00%),重度残疾2例(10.00%),植物生存0例,死亡1例(5.00%)。川穹嗪组均明显好于常规组。研究显示川穹嗪组患者的GOS预后评分显著高于常规组(P<0.05)。同时,血液动力学指标也揭示川穹嗪组患者血液循环改善情况优于常规组(P<0.05)。结论川穹嗪能改善机体血流动力学指标,对老年颅内动脉瘤术后ECI患者具有较佳的疗效。更多还原

【Abstract】 Objective To observe the influence of Ligustrazine on the hemodynamic effects and prognosis in elderly patients with early cerebral ischemia following intracranial aneurysm operation,and explore the therapeutic value.Methods 43 elderly patients with ECI following intracranial aneurysm operation were randomly divided into the Ligustrazine group(20cases),and the conventional treatment group(23cases)according to the table of random numbers.The patients in the Ligustrazine group were given intravenously Ligustrazine injection and combined with conventional therapy,whereas,other patients were given conventional treatments.Results The clinical effective rate in Ligustrazine group was significantly higher than conventional treatment group(P<0.05).Patients recovered well in conventional treatment group were 7cases(30.43%),mild disability 8cases(34.78%),severe disability 4cases(17.39%),plant survival 1case(4.34%),3cases died(13.06%),data peer-based in the Ligustrazine group were 12cases(60.00%),5cases(25.00%),2cases(10.00%),0case and 1case(5.00%),which were significantly lower than that of conventional treatment group.The prognostic scores in Ligustrazine group were apparently higher than conventional treatment group by using Glasgow outcome scale and Chinese stroke scale(P<0.05).Meanwhile,the indicators of hemodynamic effects also reflected that the Ligustrazine improved the blood circulation of patients with ECI,which was better than the conventional treatment group(P<0.05).Conclusion The Ligustrazine Phosphate for injection showed better curative effect and prognosis in elderly patients with ECI following intracranial aneurysm operation.更多还原