【摘要】 目的探索橙皮苷对脂多糖(LPS)诱导的感染性脑损伤小鼠在暗场环境中自主活动的影响。方法将45只ICR小鼠平均分为3组,即生理盐水组(对照组)、LPS组、橙皮苷组,每组15只,以ZH-ZFT型自主活动视频分析系统考察各组小鼠活动路程和穿格次数的情况。结果相对于对照组,LPS组小鼠的活动路程缩短,穿格次数减少,组间比较差异有统计学意义(P<0.05);相对于LPS组,橙皮苷组小鼠的活动路程延长,穿格次数增加,组间比较差异有统计学意义(P<0.05)。结论橙皮苷可显著增强LPS诱导的感染性脑损伤小鼠在暗场环境中的自主活动能力。更多还原

【Abstract】 Objective To study the effect of hesperidin on the locomotor activity of mice with infective brain injury induced by lipopolysaccharide(LPS)in the dark field environment.Methods 45ICR mice were randomly divided into 3 groups:Saline group,LPS group and LPS+Hesperidin group,15 mice in each group.The moving distance and the number of crossing line in the dark field were recorded using the ZH-ZFT locomotor activity video analysis system.ResultsThe LPS group had significantly shorter moving distance as well as lower frequency of the number of crossing line than those of the Saline group(P<0.05);compared with the LPS group,the Hesp group moved longer and crossed line more frequently,the differences between the two groups had statistical significance(P<0.05).Conclusion Hesperidin could significantly improve the capacity for action in the dark field of mice with infective brain injury induced by LPS.更多还原