【摘要】 目的观察经皮冠状动脉介入治疗(PCI)术患者氯吡格雷停用后血小板聚集率及血小板CD41+CD62P+表达的变化。方法对52例已服用氯吡格雷12个月但即将停药的PCI患者,比较氯吡格雷治疗前(T0)、治疗后1周(T1),停药前1周(T2)、停药后1周(T3)及停药后1个月(T4)血小板聚集率和血小板CD41+CD62P+阳性率。结果与T0比较,T1血小板聚集率及CD41+CD62P+表达均显著下降,差异有统计学意义(P<0.05);T2仍维持较低水平;T3血小板聚集率及CD41+CD62P+表达升高,T4血小板聚集率及CD41+CD62P+恢复至T0水平,T0、T1、T2、T3、T4各时间点血小板聚集率分别为(44.20±18.36)%、(25.38±12.10)%、(23.74±8.15)%、(51.79±10.55)%、(45.97±16.42)%,血小板CD41+CD62P+阳性率分别为(12.96±11.48)%、(3.93±3.33)%、(4.72±3.14)%、(13.90±10.38)%、(10.84±8.13)%。结论 PCI术后已服用氯吡格雷12个月者,停用氯吡格雷后1周时血小板聚集率、血小板CD41+CD62P+阳性率轻度增加,在停药后1个月时逐渐恢复至停药前水平。更多还原

【Abstract】 Objective To investigate the changes of platelet aggregation rate and platelet surface CD41+CD62P+expression after clopidogrel discontinuation in the patients with percutaneous coronary interventions(PCI)).Methods The platelet aggregation rates and platelet surface CD41+CD62P+in 52PCI patients with oral clopidogrel for near 12months and discontinuation soon were measured before clopidogrel therapy(T0),in 1week after clopidogrel therapy(T1),1week before clopidogrel discontinuation(T2), 1week(T3)and 1month after clopidogrel discontinuation(T4).Results Compared with T0,the platelet aggregation rate and the expression of platelet CD41+CD62P+at T1 were significantly decreased,the difference showing statistical significance(P<0.05), which at T2 maintained the lower levels;which at T3were increased,which at T4were recovered to those at T0.The platelet aggregation rates at various time points were(44.20±18.36)%,(25.38±12.10)%,(23.74±8.15)%,(51.79±10.55)%and(45.97± 16.42)%respectively,and the positive rates of CD41+CD62P+were(12.96±11.48)%,(3.93±3.33)%,(4.72±3.14)%,(13.90±10.38)%and(10.84±8.13)%,respectively.Conclusion In the patients treated with 12-month clopidogrel after PCI,the platelet aggregation rate and the CD41+CD62P+positive rate are mildly increased at 1week after clopidogrel discontinuation and gradually returned to the level before discontinuation at 1month after clopidogrel discontinuation.更多还原