【摘要】 在传统聚甲基丙烯酸甲酯(PMMA)制备的基础上,以羧甲基纤维素(CMC)和羟基磷灰石(HA)分别作为成孔剂和生物活性填料,制备多孔PMMA和多孔PMMA/HA复合材料,并用热电偶、显微CT、MTS材料试验系统和扫描电镜等比较改良后的PMMA合成物与传统PMMA最高聚合温度、抗压强度、弹性模量以及体外矿化能力等。结果显示:CMC水凝胶能显著降低传统PMMA聚合时的产热,也能使致密PMMA形成相互联通的孔径结构从而使其力学特性与人松质骨更匹配。HA颗粒的载入不会影响多孔PMMA支架的力学性能,但却能显著提高所形成复合材料的体外矿化能力。改良后的多孔PMMA/HA复合材料作为骨缺损修复材料具有良好的应用前景。更多还原

【Abstract】 Based on the conventional method to prepare dense polymethylmethacrylate(PMMA),porous PMMA and porous PMMA/hydroxyapatite(HA) cements were fabricated by adding carboxymethylcellulose(CMC) as the pore generator and HA as the bioactive filler.Thermal couple,micro-CT,tensile bench and SEM were used to evaluate the maximum temperature,compressive yield strength,modulus of elasticity and in vitro mineralization ability of cements. The results showed that the incorporation of CMC hydrogel significantly decreased the reaction temperature of cement below the normal body temperature and created the interconnected porous structure resulting in the comparable mechanical properties as human cancellous bone. The loaded HA particles enhanced the apatite-forming ability of the PMMA cement without compromising their mechanical properties. The composite cements can serve as promising candidates for bone reconstruction.更多还原