【摘要】 目的回顾性分析慢性乙型肝炎(chronic hepatitis B,CHB)患者血清乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)定量与HBV DNA水平的相关性,并确定最佳的用于确定高HBV DNA水平的HBsAg定量值的诊断临界点。方法收集2013年7月至2014年5月期间柳州市中医院确诊为CHB的患者239例,检测受试者HBV DNA、HBsAg、HBeAg及ALT水平,对检测结果进行统计学分析。结果 HBeAg阳性组CHB患者HBsAg定量和HBV DNA检测水平均高于HBeAg阴性组,且差异均有统计学意义(P均<0.05)。所有CHB患者中HBsAg定量与HBV DNA水平之间呈正相关性(r=0.603,P<0.01)。HBeAg阳性组HBsAg定量与HBV DNA水平之间呈正相关性(r=0.555,P=0.000),HBeAg阴性组HBsAg定量与HBVDNA水平之间无相关性(r=0.076,P=0.426)。在抗病毒治疗前组和治疗后组中,HBsAg定量与HBV DNA水平均有较好的正相关性(r=0.622,r=0.603,P均=0.000)。在ALT高水平组与ALT低水平组中,HBsAg定量和HBV DNA水平之间都存在正相关性(r=0.586,r=0.578,P均=0.000)。高DNA组(>2000 copies/L)患者的HBsAg定量和HBVDNA水平之间呈正相关性(r=-0.637,P=0.000),低DNA组(<2000 copies/L)患者的HBsAg定量和HBV DNA水平之间无相关性(r=0.226,P=0.057)。当HBsAg定量以5.03x103 IU/mL为临界点时,判定HBV DNA高水平的受试者工作特征曲线下面积最大,为0.727。结论 CHB患者血清HBsAg定量值与HBV DNA水平呈正相关。血清HBsAg定量值可以较好地预测高HBV DNA水平。更多还原

【Abstract】 Objective To analysis the relevance of the serum HBsAg and HBV DNA levels in patients with chronic hepatitis B(CHB),and to detect the HBsAg critical point levels used to determine the best high HBV DNA.Methods 239 cases CHB patients in Liuzhou Traditional Chinese Medicine Hospital from July2013 to May 2014 were collected.The levels of HBV DNA,HBsAg,HBeAg and ALT were detected.The results were analyzed statistically.Results The levels of HBsAg and HBV DNA in HBeAg positive group were all higher than that of HBeAg negative group,and the differences all had statistical significance(Pall< 0.05).The levels of HBsAg and HBV DNA were positive correlated in all the CHB patients(r= 0.603,P< 0.01).The levels of HBsAg and HBV DNA were positive correlated in HBeAg positive group(r= 0.555,P= 0.000),but there was no correlation in HBeAg negative group(r= 0.076,P- 0.426).The levels of HBsAg and HBV DNA were all positive correlated in before antiviral therapy group and after antiviral therapy group(r= 0.622,r=0.603,Pall= 0.000).The levels of HBsAg and HBV DNA were all positive correlated in high ALT group and low ALT group(r= 0.586.r= 0.578,Pall= 0.000).The levels of HBsAg and HBV DNA were positive correlated in high HBV DNA(> 2000 copies/L) group(r= 0.637,P= 0.000),but there was no correlation in low HBV DNA(< 2000 copies/L) group(r= 0.226,P= 0.057).HBsAg levels used to determine the best high HBV DNA critical point was 5.03 × 10~3 IU/mL,and the area under receiver operating characteristic curve was 0.727.Conclusion There are positive correlation between serum HBsAg and HBV DNA levels in CHB patients.HBsAg levels can be used for speculated the high levels of serum HBV DNA.更多还原