【摘要】 以乙酰乙酸乙酯、氯化苄和氢氧化钾为原料,在相转移催化剂的作用下合成了2-苄基乙酰基乙酸乙酯。考察了反应时间、反应温度、催化剂类型和用量以及投料比等对产品收率的影响。结果表明,优化工艺条件为:以四丁基溴化铵为催化剂,水为溶剂,n(乙酰乙酸乙酯)∶n(氯化苄)∶n(氢氧化钾)∶n(水)∶n(四丁基溴化铵)=1∶1.15∶1.2∶7.4∶0.012,反应温度100℃,反应时间5 h,此条件下产品收率达90.54%。更多还原

【Abstract】 Ethyl 2- benzylacetoacetate was synthesized with ethyl acetoacetate,benzyl chloride and potassium hydroxide as starting materials and tetrabutylammonium bromide as phase transfer catalyst. Effects of reaction time,reaction temperature,catalyst dosage and the molar ratio of the reactants were examined. Results showed that under the optimized reaction conditions as: mole ratio,n( ethyl acetoacetate) ∶ n( benzyl chloride) ∶ n( KOH) ∶ n( H2O) ∶ n( tetrabutylammonium bromide) = 1 ∶ 1. 15 ∶ 1. 2 ∶ 7. 4 ∶ 0. 012; reaction temperature, 100 ℃ for 5 h; yield of the product reaches 90. 54%.更多还原