【摘要】 目的:探讨CD147在胃肠道癌中的表达情况和意义。方法:应用免疫组化法检测胃肠道癌(n=996)和癌旁正常黏膜(n=110)中CD147的表达情况,并分析CD147表达与胃肠道癌临床病理特征和预后的关系。结果:胃肠道癌CD147的阳性表达率明显高于正常黏膜(P<0.01)。胃肠道癌CD147的表达与年龄、肿瘤大小、静脉侵袭和淋巴管侵袭有关(P<0.05);与性别、淋巴结转移及UICC分期无关(P>0.05)。Kaplan-Meier曲线显示CD147表达与患者的预后无明显相关性(P>0.05)。结论:CD147参与胃肠道癌的发生和局部浸润,可作为反应胃肠道癌病理生物学行为的有效分子标志。更多还原

【Abstract】 Objective:To investigate the expresion and significance of CD147 in gastrointestinal cancer. Methods:Immunohistochemical staining was used to detect the expression of CD147 in 996 cases gastrointestinal cancer and 110 cases para-carcinoma normal mucosa, and analyzed the relationships between CD147 expression and clinicopathologic features and prognosis of gastrointestinal cancer.Results:The expression of CD147 in gastrointestinal cancer was obviously higher than that in normal mucosa(P< 0.01). In gastrointestinal cancer, the CD147 expression was nothing to do with sex, lymph node metastasis and UICC stage(P> 0.05); but was associated with age, tumor size, venous invasion and lymphatic vessel invasion(P< 0.05). Kaplan-Meier curve showed CD147 expression had no signifi cant correlation with the prognosis of gastrointestinal cancer patients(P> 0.05).Conclusions: CD147 participates the development of gastrointestinal cancer, and can be acted as effective molecular marker to reveal the biological behavior of gastrointestinal cancer.更多还原