目的:研究借助磁共振成像(magnetic resonance imaging,MRI)可定位的Eudragit-E液体栓塞剂(MR-E)的制备方法,并对其体外和体内的性质进行研究。方法:采用化学共沉淀法制备聚乙二醇修饰的超顺磁性氧化铁(polyethylene glycol-modified superparamagnetic iron oxides,PEG-SPIO),将PEG-SPIO和Eudragit-E液体栓塞剂混合均匀制得MR-E。通过体外MRI实验考察MR-E的成像性质,并筛选PEG-SPIO的浓度。通过经微导管推注实验和体外固化实验考察MR-E的推注性能和固化性质。以家兔肾动脉为栓塞模型,考察MR-E的体内栓塞效果和磁共振成像性质。结果:MR-E中PEG-SPIO的浓度确定为2 g/L,MR-E具有良好的推注性能和固化性质,0.2 mL MR-E注入家兔肾动脉后,可以有效地栓塞肾动脉远端血管,并且通过MRI可以示踪MR-E的组织分布情况。结论:MR-E有望成为一种新型的借助MRI可定位的液体栓塞剂。
【英文摘要】
Objective:To develop and investigate the properties of MRI-traceable Eudragit-E liquid embolic agent( MR-E). Methods: Polyethylene glycol-modified superparamagnetic iron oxides( PEGSPIO) was synthesized by chemical co-precipitation method. MR-E was prepared by mixing PEG-SPIO and Eudragit-E liquid embolic agent homogeneously. An in vitro MR phantom study was carried out to measure MR traceability of MR-E and to determine the concentration of PEG-SPIO for further studies.The microcatheter deliverability and ...
【更新日期】
2014-11-13
【分类号】
R943
【正文快照】
partment of Radiology,Peking University Third Hospital,Beijing 100191,China;3.Department of Interventional Radiolo-gy and Vascular Surgery,Peking University First Hospital,Beijing 100034,China)△Corresponding author’s e-mail,tianyuan_fan@bjmu.edu.cn经导?
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