节点文献

浅谈葛根素对β细胞的保护作用

Concise review on the protective effects of puerarin on β-cell

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 杨蕾舒娈姚冬冬贾晓斌余嗣明

【Author】 YANG Lei;SHU Luan;YAO Dong-dong;JIA Xiao-bin;YU Si-ming;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine;School of Life Sciences, Anhui University;

【机构】 江苏省中医药研究院,国家中医药管理局中药释药系统重点研究室安徽大学生命科学学院

【摘要】 近年来世界各国糖尿病发病率呈现急剧增加的趋势,因此,进一步加强对糖尿病发病机制的研究,拓展糖尿病治疗药物研发新思路,治疗的新策略,是目前医药界面临的一项迫切任务。中医药治疗糖尿病历史悠久,其中葛根被应用于众多经典降糖方,如葛根芩连汤。葛根素是葛根的主要活性成分,可以促进胰岛β细胞增殖、生长,并减少凋亡,保护胰岛β细胞功能,使受损胰岛细胞得以修复并恢复功能。基于β细胞功能衰竭是引起糖尿病的重要病因,保护胰岛β细胞成为治疗糖尿病的有效方法。文章将着重对葛根素保护胰岛β细胞的作用机制进行探讨。

【Abstract】 In recent years, incidence of diabetes around the world presented a dramatic rise trend. Therefore, to further study of the pathogenesis of diabetes, develop the new idea of diabetes drug research and new strategies of treatment were urgent task faced by the current medicine field. There was a long history of treating diabetes with TCM. Puerarin was applied in many classic formula of reducing blood glucose, such as Gegen Qinlian Decoction. Puerarin as the major effective component of pueraria, could promote β-cell proliferation, reduce β-cell apoptosis, protect β-cell function, repair the damaged β-cell and restore its function. The loss and dysfunction of the pancreatic β-cell were the crucial pathophysiologic mechanism for the onset and development of diabetes, and protective function of β-cell would be a promising strategy for diabetes treatment. In this article, the discussion would focus on β-cell protective mechanism of puerarin.

【基金】 国家自然科学基金项目(No.81102488);江苏省自然科学基金项目(No.BK2011865)~~
  • 【文献出处】 中华中医药杂志 ,China Journal of Traditional Chinese Medicine and Pharmacy , 编辑部邮箱 ,2014年11期
  • 【分类号】R259
  • 【被引频次】27
  • 【下载频次】452
节点文献中: 

本文链接的文献网络图示:

本文的引文网络