【摘要】 目的评价孕妇血浆中不规则抗体检查在非ABO新生儿溶血病(Non-ABO-HDN)早期预测的应用价值。方法应用抗球蛋白试验对3 493例孕妇血浆标本进行不规则抗体筛选,结果阳性者进一步鉴定其特异性,并对结果进行分析。结果不规则抗体筛选阳性11例,阳性率为0.31%,其中IgG抗-M 3例(27.3%)、IgM抗-M 2例(18.2%)、IgG抗-D 5例(45.4%)、IgG抗-E 1例(9.1%)。11例不规则抗体阳性孕妇中,1例孕妇随防脱落,6例HDN检测阳性,阳性预测值为60%(6/10)。结论孕妇血浆不规则抗体检测,有助于Non-ABO-HDN的早期预测,从而对预防和及时治疗核黄疸等严重并发症有具有较大意义。更多还原

【Abstract】 Objective Evaluateingthe application value of irregular antibody detection in the pregnant women plasma in early prediction of non ABO hemolytic disease of the newborn. Methods Coombs Test was used to screen the irregular antibodies in 3493 plasma samples of pregnant women,the specificity of the irregular antibodies were further identified in the positive samples. Results there were 11 positive,the positive rate was 0. 31%,in which 3 samples( 27. 3%) were IgG antiM,2 samples( 18. 2%) were IgM anti-M,5 samples( 45. 4%) were IgG anti-D,and 1 sample( 9. 1%) was IgG anti-E-. During the follow-up visit of the 11 patients,one was out of touch,and six patients undergone HDN,the positive predictive value was 60%( 6 /10). Conclusion Irregular antibody screening in the pregnant women plasma is conducive to earlypredict the Non-ABO-HDN,and it has a great significance in prevention and timely treatment of serious complications of hemolytic disease such as kernicterus.更多还原