【摘要】 目的用不同剂量的优甲乐(L-T4)干预131I治疗甲亢后对早发甲减的影响。方法 218例Graves病患者,按照随机分组分为3组,A组69例,单纯给予131I治疗作为对照组;B组78例,131I治疗后21天起用L-T4 25μg/d连续治疗20天;C组71例,131I治疗后21天起用L-T4 100μg/d连续治疗20天;通过测定甲功观察131I治疗后早发甲减发生率及首次甲亢治愈率。结果131I治疗后3月、6月、12月甲减的发生率及首次甲亢的治愈率A组分别为8.72%、12.33%、20.28%、81.16%;B组分别为4.29%、5.49%、7.69%、76.92%;C组分别为4.37%、5.02%、7.04%、61.97%。结论小剂量的优甲乐能降低131I治疗后早发甲减的发生率,同时甲亢的治愈率又不下降。更多还原

【Abstract】 Objective To explore the impact of interference through different does of Euthyrox( L-T4) on the early hypothyroidism of patients with hyperthyroid after131I treatment. Methods 218 patients with Graves’ disease were divided into 3 random groups. Group A contained 69 patients only treated by131I and severed as control group; Group B had 78 samples which gave L-T4 25 μg /d for the next successive 20 days after 21 day of131I treatment. Group C had 71 samples which gave L-T4 100μg /d for the next successive 20 days after 21day of131I treatment. The early hypothyroidism rate and the cure rate of hyperthyrosis were observed by measurement of thyroid function. Results The early hypothyroidism rate and the cure rate of hyperthyrosis of group A after 3,6,12 months treated by131I were 8. 72%,12. 33%,20. 28% and 81. 16% respectively.Group B were 4. 29%,5. 49%,7. 69% and 76. 92%. Group C were 4. 37%,5. 02%,7. 04% and61. 97%. Conclusion Small does of Euthyrox could reduce the early hypothyroidism rate in patients with hyperthyrosis after131I treatment I and would not reduce the cure rate of hyperthyrosis.更多还原