【摘要】 目的:探讨左卡尼汀(LC)治疗非酒精性脂肪肝(NAFLD)的疗效。方法:62例NAFLD患者,随机分为LC治疗组(LC组)32例和安慰剂对照组30例,LC组予LC口服,每次1 g,早晚饭后各1次,疗程共24周。记录治疗前后患者血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、三酰甘油(TG)、总胆固醇(TC)、C反应蛋白(CRP)、空腹血糖(FBG)、胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平,以及肝脏超声表现。结果:与治疗前和对照组比较,LC组治疗后ALT、AST、GGT、TG,TC、FINS、HOMA-IR值均明显降低(P<0.01),肝脏B超明显改善,总有效率明显高于对照组(P<0.01)。结论:左卡尼汀可有效改善NAFLD患者肝功能、血脂,减轻胰岛素抵抗,能安全有效地用于治疗NAFLD。更多还原

【Abstract】 Objective: To explore of the effects of L-carnitine( LC) in the treatment of nonalcoholic fatty liver disease( NAFLD).Methods: Sixty-two patients with NAFLD were randomly divided into the LC treatment group( LC group)( 32 cases) and placebo control group( 30 cases). The LC group were treated with 1 g of LC by oral,twice a day for 24 weeks after breakfast and dinner. The levels of serum alanine aminotransferase( ALT),aspartate aminotransferase( AST),γ-glutamyltransferase( GGT),triglyceride( TG),total cholesterol( TC),C reactive protein( CRP),fasting plasma glucose( FBG),insulin( FINS),insulin resistance index( HOMA-IR)and liver ultrasound in all patients were recorded before and after treatment. Results: Compared with the before treatment and control group,the levels of ALT,AST and GGT,TG and the TC,FINS and HOMA-IR of LC group decreased significantly( P < 0. 01),and the liver B ultrasound was improved obviously after treatment. The total effective rate of the LC group was significantly higher than that in control group( P < 0. 01). Conclusions: L-carnitine can effectively improve the liver function and blood lipid,and reduce the insulin resistance of patients with NAFLD,which is a safe and effective drug in the treatment of NAFLD.更多还原