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抑癌蛋白p33(ING1)对肿瘤作用的研究进展
Research Progress of Tumor Suppressor p33(ING1) Effects on Neoplasia
【摘要】 p33(ING1)是生长抑制基因(ING1)编码的重要抑癌蛋白,具有抑制细胞生长﹑促进细胞老化﹑维持基因组稳定性、作用于细胞周期调控点等作用,其失活与肿瘤的发生、发展密切相关。本文就近年来有关p33(ING1)的结构、功能及其在肿瘤中的失活机制、临床应用前景等方面的研究进展进行了概述。
【Abstract】 p33ING1is an important tumor suppressor protein encoded by the tumor-suppressor gene ING1,which plays roles in arresting cell growth,promoting cell aging,maintaining genomic stability and acts on the checking point of cell cycle.p33ING1 has close relationship with tumorigenesis and tumor progression.In this review the structure and function,clinical prospect,mechanism and significance of the p33(ING1)in human neoplasia are summarized.
【关键词】 p33(ING1b)蛋白;
肿瘤抑制基因;
肿瘤形成;
【Key words】 p33(ING1)protein; tumor suppressor gene; formation of neoplasia;
【Key words】 p33(ING1)protein; tumor suppressor gene; formation of neoplasia;
- 【文献出处】 氨基酸和生物资源 ,Amino Acids & Biotic Resources , 编辑部邮箱 ,2014年04期
- 【分类号】R730.2
- 【下载频次】58