【摘要】 目的观察三氧化二砷动静脉联合应用配合经导管动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)的疗效。方法将50例中晚期肝癌患者随机分成三氧化二砷联合TACE治疗组(试验组)和单纯TACE治疗组(对照组),比较两组实体瘤近期疗效、生活质量改善情况及血清甲胎蛋白变化情况。结果两组实体瘤近期疗效比较,差异无统计学意义(P>0.05)。试验组在改善生活质量方面显著优于对照组(P<0.05)。两组血清甲胎蛋白下降率比较,差异无统计学意义(P>0.05)。结论三氧化二砷动静脉联合应用配合TACE治疗中晚期原发性肝癌疗效确切,可提高患者的生活质量。更多还原

【Abstract】 Objective To investigate the efficacy of combined intra-arterial and intravenous arsenic trioxide plus transcatheter arterial chemoembolization(TACE)in the treatment of advanced hepatocellular carcinoma(HCC).Methods Fifty patients with advanced HCC were randomly divided into experimental group and control group.The experimental group received combined intra-arterial and intravenous arsenic trioxide plus TACE,while the control group underwent TACE alone.The short-term outcome of solid tumor,improvement in quality of life(QOL),and change in serum alpha-fetoprotein(AFP)were compared between the two groups.Results There was no significant difference in the short-term outcome of solid tumor between the two groups(P>0.05).The experimental group had a significantly more improvement in QOL than the control group(P<0.05).The decrease in serum AFP level showed no significant difference between the two groups(P>0.05).Conclusion Combined intra-arterial and intravenous arsenic trioxide plus TACE is effective in the treatment of advanced HCC and can improve patients’QOL.更多还原