【摘要】 目的探讨原发性肝癌的危险因素和肝癌病发的相关性,为其预防提供参考。方法选择2009年9月至2013年1月期间在该院治疗的原发性肝癌患者256例作为观察组,选择同时期健康体检者358例作为对照组。调查两组HBV感染、饮酒、饮茶、食用剩饭菜、食用腌制食品、吸烟、家族肝癌史、慢性肝病史、文化程度、生活质量等情况,并进行logistic回归分析,应用比值比(OR)和95%可信区间(95%CI)进行评估。结果观察组和对照组在HBV感染、饮酒、饮茶、食用剩饭菜、食用腌制食品、吸烟、家族肝癌史、慢性肝病史、文化程度、生活质量等方面均存在显著差异,经多因素非条件Logistic回归分析,HBV感染、饮酒、饮茶、食用剩饭菜、家族肝癌史、慢性肝病史、生活质量其OR值分别为13.524、4.856、0.080、3.806、24.691、19.815和0.095,95%CI分别为6.952~18.625、3.784~7.367、0.059~0.605、3.018~8.224、10.890~35.265、8.754~29.543和0.275~0.569。结论 HBV感染、饮酒、家族肝癌史、慢性肝病史、食用剩饭菜可能是原发性肝癌的主要危险因素;吸烟和吃食用腌制食品可能是其次要危险因素;饮茶和生活质量则可能是其重要保护因素;文化程度可能是其次要保护因素。更多还原

【Abstract】 Objective To explore the risk factors of primary liver cancer and liver disease,to provide reference for its prevention. Methods From September 2009 to January 2013,256 patients with primary liver cancer were selected as observation group in our hospital, 358 cases of healthy physical examination in our hospital were selected as control group. Two groups were surveyed in the aspect of HBV infection,alcohol,drinking tea,eating leftovers,pickled foods,smoking,family history of liver cancer,the degree of chronic liver disease history,culture,quality of life,etc. Then two groups were in the logistic regression analysis,and they were applied odds ratio( OR) and 95% confidence intervals( 95% CI) for evaluation. Results Between observation group and control group in HBV infection,alcohol, drinking tea,eating leftovers,pickled foods,smoking,family history of liver cancer,the degree of chronic liver disease history,culture, quality of life aspects there were significant differences. The multi-factor unconditioned Logistic regression analysis showed that OR values of HBV infection,alcohol,drinking tea,eating leftovers,family history of liver cancer,history of chronic liver disease,and quality of life were 13. 524,4. 856,0. 080,3. 806,24. 691,19. 815 and 0. 095,and the 95% CI values were 6. 952 ~ 18. 625,3. 784 ~ 7. 367, 0. 059 ~ 0. 605,3. 018 ~ 8. 224,10. 890 ~ 35. 265,8. 754 ~ 29. 543 and 0. 075 ~ 0. 569. Conclusions HBV infection,alcohol consumption,family history,history of chronic liver disease and liver cancer eating leftovers can be major risk factors for primary liver cancer. Smoking and eating pickled foods may be the second risk factors. Drinking tea and quality of life may be important protective factors. Cultural level is likely to be secondary to protective factors.更多还原