【摘要】 目的:研究2,4-二氯苯氧乙酸(2,4-D)是否具有潜在的遗传毒性。方法:利用Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠睾丸初级精母细胞染色体畸变试验对2,4-D原药的致突变性进行研究。结果:与对照组比较,2,4-D原药各剂量组对TA97、TA98、TA100和TA102菌株均无诱发回复突变菌落数增加的作用(P>0.05),对小鼠骨髓嗜多染红细胞的微核细胞率亦无明显影响(P>0.05),也未引起小鼠睾丸初级精母细胞染色体畸变率明显改变(P>0.05)。结论:在本实验条件下,未发现2,4-D原药的致突变性。更多还原

【Abstract】 OBJECTIVE: To explore the potential mutagenicity of 2,4-dichlorophenoxyacetic acid. METHODS:Ames test,mouse bone marrow micronucleus test and mouse primary spermatocyte chromosome aberration test were conducted. RESULTS:Ames test showed no two- fold increase in the spontaneous reversion colonies compared with the negative control group(P>0.05). No significant difference was found in chromosome aberration and micronucleus rate between control and experimental groups(P>0.05). CONCLUSION:2,4-dichlorophenoxyacetic acid showed no mutagenicity under these test conditions.更多还原