【摘要】 目的研究南方红豆杉水提物对人胃腺癌细胞株SGC-7901和人乳腺癌株MCF-7增殖的抑制作用和机制。方法采用二苯基四氮唑溴盐比色法(MTT法)检测南方红豆杉水提物和紫杉醇对SGC-7901和MCF-7细胞增殖的抑制作用;光镜观察其对2种细胞形态的影响;流式细胞仪检测其对2种细胞凋亡的影响。结果南方红豆杉水提物对肿瘤细胞的增殖有抑制作用;其抑制作用机制为诱导细胞凋亡。结论南方红豆杉水提物对肿瘤细胞的增殖有抑制作用.更多还原

【Abstract】 Objective To study the inhibitory effects of Taxus chinensis var. mairei Aqueous Extract (TAE) on SGC-7901 and MCF-7 cells, and to explore its mechanisms. Methods The inhibitory effects of TAT and Paclitaxel on the proliferation of SGC-7901 and MCF-7 cells were tested by MTT method. Their effects on the morphology of SGC-7901 and MCF-7 cells were observed by microscope. Its effects on the cell apoptosis were detected by flow cytometry. Results The TAE had inhibitory effects on the proliferation of tumor cells, and its mechanisms were correlated to inducing the apoptosis of tumor cells. Conclusion TAE had inhibitory effects on the proliferation of tumor cells.更多还原