【摘要】 目的:研究楤木皂苷对四氯化碳致大鼠肝纤维化的防治作用,并探讨其作用机制。方法:采用40%四氯化碳皮下注射诱导大鼠肝纤维化模型,楤木皂苷给药8周,检测大鼠肝脾指数、肝功能及血清透明质酸(HA)、三型胶原(COI-Ⅲ)、四型胶原(COI-Ⅳ)的变化。结果:楤木皂苷(30 mg/kg、60 mg/kg)可改善肝功能,降低肝脾指数及血清HA、COI-Ⅲ、COI-Ⅳ的含量。结论:楤木皂苷可改善肝功能,有抗纤维化作用。更多还原

【Abstract】 Objective: To study the protective effects of Aralia saponins against carbon tetrachloride(CCl 4) induced liver fibrosis in rats and investigate its mechanism.Methods: The rat model of liver fibrosis was induced by hypodermic injection of 40% CCl 4.The models were intragastric administrated by Aralia saponins for 8 weeks.Liver and spleen indexes,hepatic function,serum levels of HA,COI-Ⅲ,COI-Ⅳ were detected.Results: Aralia saponins(30 mg / kg、60 mg / kg) can improve hepatic function,and reduce liver and spleen indexes,HA,COI-Ⅲ,COIⅣ in serum(P 0.05).Conclusion: Aralia saponins can ameliorate liver function and prevent hepatic fibrosis.更多还原