【摘要】 目的了解和探讨育龄人群红细胞平均体积(MCV)、红细胞分布宽度(RDW)与地中海贫血类型的相关性及诊断价值。方法采用血细胞分析仪测定MCV和RDW-CV,筛选出疑地贫者采用聚合酶链反应(PCR)及反向点杂交技术(RDB)进行地中海贫血分型。结果 MCV<60fl且RDW-CV>15%疑地贫者中,α型地贫只有4例,占8.7%,β型地贫有38例,占82.6%;MCV>60fl且RDW-CV<15%的疑地贫者中,α型地贫有172例,占67.7%,β型地贫只有6例,占2.4%;两者之间存在明显的差异(P<0.01)。结论育龄人群进行血常规检查,其MCV和RDW值作为地中海贫血的简便可行的筛查手段具有较高的临床诊断价值。更多还原

【Abstract】 Objective:To analyse and evaluate the relation and the clinical value of mean corpuscular volume(MCV) and red blood cell volume distribution width(RDW) in reproductive people.Methods:Examining MCV and RDW by molecular biologic technique.Samples of uncertain thalassmia were detectde by gene test(PCR and RDB).Result: Among the samples of the uncertain thalassmia of MCV<60fl and RDW-CV>15%,alpha-thalassmia were 4(8.7%),beta-thalassmia were 38(82.6%).Among the samples of the uncertain thalassmia of MCV>60fl and RDW-CV<15%,alpha-thalassmia were 172(67.7%),beta-thalassmia were 6(2.4%).There were obvious different(P<0.01).Conclusion: It is effective and convient to test MCV and RDW-CV by molecular biologic technique in screening out thalassemia in reproductive people.更多还原