【摘要】 目的:观察同型半胱氨酸(Hcy)与脑梗死的关系;探讨头体针对高同型半胱氨酸血症的影响及对脑梗死的防治。方法:收集70例急性脑梗死患者随机分为治疗组、对照组,测定血浆Hcy、叶酸、维生素B12的浓度。对Hcy及脑血管危险因素与脑梗死TOAST分型各亚型之间的关系进行分析。并进行神经功能缺损评分(NIHSS)和日常生活活动能力(Barthel)指数评分。结果:脑梗死患者血浆Hcy浓度高于健康对照组,Hcy与叶酸、维生素B12呈负相关。血浆Hcy水平在TOAST1型和TOAST2型脑梗死中明显升高。Hcy与传统危险因素无明显相关。治疗后血浆Hcy水平明显降低,头体针可降低NIHSS评分、提高Barthel指数,且优于对照组。结论:高同型半胱氨酸血症可能是导致脑梗死的独立危险因素,头体针疗法可显著降低脑梗死患者血浆Hcy水平,能够减轻脑梗死患者临床神经功能缺损程度、改善日常生活活动能力。更多还原

【Abstract】 Objective:To study the relationship between homocysteine and cerebral infarction,and to explore the effects of scalp and body acupuncture on hyperhomocysteinemia and prevention of cerebral infarction.Methods:70 acute cerebral infarction patients were collected.They were randomized divided into the scalp and body acupuncture group and the control group.The concentrations of Hcy,folate and vitamin B 12 were determined.The relationship of Hcy,vascular risk factors and TOAST were analyzed.We compared the NIHSS score and the BI index.Results:The plasma homocysteine levels of acute cerebral infarction were significantly higer than those in the health control group.The level of Hcy was negatively correlated with folate and vitamin B 12.The level of plasma Hcy increased significantly among patients of TOAST 1 and 2.There was no association between plasma homocysteine and traditional risk factors.The level of Hcy were obviously decreased.NIHSS scores were decreased and BI was obviously improved in the treatment group which was much better than the control group.Conclusion:Hyperhomocysteinemia probably is an independent risk factor for cerebral infarction.The scalp and body acupuncture can obviously decrease the levels of Hcy of the acute cerebral infarction patients,alleviate clinical nerve function damage degree and improve activities of daily living.更多还原