【摘要】 目的:探讨当归散对先兆流产大鼠模型的安胎作用。方法:采用药物米非司酮加米索前列醇的方法建立先兆流产的大鼠模型,监测大鼠阴道出血时间,观察各组的平均胎仔数、胎仔重量、子宫重、胎盘重量等情况,观察子宫瘀血、胎仔畸形或死胎情况,以了解胚胎生长和发育情况;测定孕酮、雌二醇水平。结果:模型组大鼠出现阴道出血症状,持续时间全部长达52h以上,治疗组分别有一定程度的减轻。模型组与正常组比较,平均胎仔数无明显变化;但胎仔总重、平均每胎重、子宫重量和胎盘重量明显减轻(P<0.05),差异有显著性意义;模型组胎仔总数中约有20.02%出现瘀血,17.62%是畸形胎或死胎。当归散对以上情况有所逆转;各组孕酮、雌二醇水平无明显差异。结论:当归散安胎作用疗效肯定,有待进一步实验研究。更多还原

【Abstract】 Objective:To investigate the effects of Danggui powder on preventing miscarriage in rat models.Methods:Establish the threatening miscarriage in the rat models by intragastric infusion of Mifepristone and Misoprostol,Monitor rats vaginal bleeding time,put the pregnant rats to death to observe all groups’ number of litters,the weight of fetus,the weight of uterus and the weight of placenta,observe uterine blood stasis,and fetal malformation,realize the growth and development of embryo;determinate levels of progesterone and estradiol.Results: The model group had vaginal bleeding and the time for 52 hours or more,the treatment groups were certain degree of ease separately.Compared with normal group,the model group had no change on number of litters,but less obviously on the weight of all fetus and average fetus,the weight of uterus and the weight of placenta,the difference had a statistical significance(P<0.05).20.02% of all model fetus had blood stasis,17.62% of all model fetus were fetal malformation.Danggui powder could dwindle these numbers.Levels of progesterone and estradiol between all groups had no significant difference.Conclusion: Therapy of Danggui powder for threatened abortion deserves affirmation,and further experiments are necessary.更多还原