【摘要】 目的:建立气相色谱法测定马来酸氯苯那敏乳膏中马来酸氯苯那敏和防腐剂羟苯乙酯含量的方法。方法:采用HP-5石英毛细管柱经程序升温技术分离待测组分,内标法计算含量。进样口温度:270℃;FID检测器,检测器温度280℃;进样量1μl。结果:各组分分离良好,马来酸氯苯那敏在0.2～2.0 mg·ml^-1（r=0.999 6）,羟苯乙酯在0.125～1.250 mg·ml^-1（r=0.999 7）范围内呈良好线性关系,平均加样回收率马来酸氯苯那敏为98.45%（RSD=1.13%,n=6）,羟苯乙酯为97.92%（RSD=0.48%,n=6）。结论:该法简便快速,结果准确,可用于测定该药品的含量。更多还原

【Abstract】 Objective:To establish a method for the determination of chlorphenamine and the preservative ethyiparaben in chlorphenamine creams by GC.Method:The samples were isolated by an HP-5 silicon capillary column,and the temperature was raised by temperature programming.The results were detected by an internal standard method.The injector temperature was at 270℃,and the FID detector temperature was at 280℃.Result:Good separation was obtained in the quantitative determination.The calibration curves showed good linear relationship within the range of 0.2-2.0 mg ? ml^-1（r = 0.999 6） and 0.125-1.25 mg ? ml^-1（r = 0.999 7） for chlorphenamine and ethyiparaben,respectively.The average recovery of chlorphenamine and ethyiparaben was 98.45%（RSD - 1.13%,n =6） and 97.92%（RSD =0.48%,n =6）,respectively.Conclusion:The method is convenient,rapid,accurate and suitable for the determination of the preparation.更多还原