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灵芪胶囊对S180荷瘤小鼠IL-1和IL-6蛋白表达的影响

Effect of Lingqi Capsules on the Expression of IL-1 and IL-6 Protein in S180 Tumor-bearing Mice

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【作者】 王国胜苏慧刘萍李环苏云明

【Author】 Wang Guosheng~1,Su Hui~2,Liu Ping~2,Li Huan~2,Su Yunming~2(1.The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2.Heilongjiang University of Traditional Chinese Medicine)

【机构】 哈尔滨医科大学附属第一医院黑龙江中医药大学

【摘要】 目的:研究灵芪胶囊对S180荷瘤小鼠的抗肿瘤作用,并探讨其可能的作用机制。方法:将S180瘤株接种于小鼠右前肢腋部皮下建立动物模型,并采用ELISA法检测小鼠外周血IL-1和IL-6蛋白含量。结果:灵芪胶囊能明显增加S180荷瘤小鼠外周血IL-1和IL-6蛋白含量,能改善和增强荷瘤小鼠的免疫功能。结论:灵芪胶囊对S180荷瘤小鼠有明显抑瘤作用,其作用机制可能是通过改善小鼠免疫功能而实现的。

【Abstract】 Objective:To study the effect of Lingqi capsules in S180 tumor-bearing mice and explore the possible mechanisms. Method:The tumor-bearing mice were obtained by the axillary subcutaneous inoculation of S180 strains in right forelimb,and the contents of IL-1 and IL-6 protein in peripheral blood of mice were detected by ELISA method.Result:Lingqi capsules could significantly increase the contents of IL-1 and IL-6 protein in peripheral blood of the tumor-bearing mice to improve the immune function.Conclusion: Lingqi capsules show apparent anti-tumor effect in S180tumor-bearing mice,and the effect can be achieved by improving the immune function.

【关键词】 灵芪胶囊抗肿瘤S180白介素-1白介素-6
【Key words】 Lingqi capsulesAnti-tumorS180IL-1IL-6
【基金】 黑龙江中医药大学攻关课题(编号:GC05C31403)
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】83
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