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基于MEMS技术的高密度视网膜假体微电极阵列的研制
The Research on High-Density Flexible Microelectrode Array of Retinal Prosthesis Based on MEMS Technology
【摘要】 提出了一种基于MEMS技术设计和制作应用于视网膜假体的柔性神经微电极阵列的工艺流程,引入离子束刻蚀的工艺大幅度减小了导线和线间的宽度,在单层聚合物上制作了高密度的微电极阵列(120通道,10×12阵列)。对实际制得的微电极阵列测试表明,其在1 kHz频率的电脉冲刺激下阻抗均值为16 kΩ±2 kΩ,相位差均值为-85o±3o,达到了预期设计目标。
【Abstract】 The paper proposed a new method to design and fabricate a fexible neural microelectrode arrays(MEA) for retinal prosthesis, the Ion-Beam technology was intruduced to decrease the width of conductive wires and the distances between wires, a high density MEA(120 microelectrodes with a matrix of 10×12) was fabricated on a single layer of polymer from this. The MEA was proved to possess a fine electrochemical property. In vitro test, the average impedance of MEA on 1 kHz was 16 kΩ±2 kΩ and the average phase difference was-85o±3o.
【关键词】 视觉假体;
视网膜假体;
微电极阵列;
MEMS;
高密度;
【Key words】 visual prosthesis; retina prosthesis; micro electrode array; MEMS; high density;
【Key words】 visual prosthesis; retina prosthesis; micro electrode array; MEMS; high density;
【基金】 国家重点基础研究发展计划(973项目:2011CB707503/05);国家自然科学基金(61273368);国家高技术研究发展计划(863项目:2009AA04Z326)
- 【文献出处】 中国医疗器械杂志 ,Chinese Journal of Medical Instrumentation , 编辑部邮箱 ,2013年06期
- 【分类号】R318.18
- 【被引频次】4
- 【下载频次】154