【摘要】 目的了解桂北地区儿童耐甲氧西林金黄色葡萄球菌(MRSA)的感染特点和耐药状况,为临床诊治提供参考。方法对2009-03～2012-10桂林医学院附属医院感染MRSA的患儿的临床特点进行调查,用头孢西丁纸片法鉴定MRSA,采用VITEK32全自动微生物分析仪GPS药敏板,检测MRSA分离株对20种抗菌药物的敏感性。结果分离金黄色葡萄球菌(SAU)289株,MRSA51株,MRSA分离率为17.65%,检出MRSA较多的标本是脓液和分泌物,检出MRSA的患儿中0～3岁者40例(78.43%)。所有MRSA的分离株都对青霉素和苯唑西林耐药,对头孢菌素类药物的耐药率较高,对克林霉素敏感率为53%,对复方新诺明、诺氟沙星、利福平的敏感率较高,对万古霉素、夫西地酸、替考拉宁、左旋氧氟沙星、米诺环素、呋喃妥因、达福普汀100%敏感。结论桂北地区儿童MRSA分离株多见于婴幼儿,万古霉素、夫西地酸、替考拉宁、达福普汀、复方新诺明、呋喃妥因、利福平具有较高的敏感率,可以考虑常规用于治疗桂北地区MRSA引起的儿童感染。更多还原

【Abstract】 Objective To investigate antibiotic resistance of methicillin-resistant Staphylococcus aureus(MRSA)from children with MRSA infection and its clinical characteristics,in order to provide information for clinic.Methods Total of children with MRSA infection were investigated by us in the Hospital Affiliated of Guilin Medical College from March 2009 to October 2012. The strains of MRSA were identified by cefoxitin slip test, the antimicrobial sensitivity tests of MRSA to 20 kinds of drugs were tested by VITEK32 automatic microbial monitor GPS.Results There were totally 289 strains of Staphylococcus aureus isolated from various clinical specimens obtained from 289 children, among which there were 51 strains of MRSA with the detection rate of 17.65%; The most common locus where MRSA was positive were liquor puris and secretion. The most common age with MRSA infection was 0~3 year old, which accounted 78.43%.The resistance rate to Penicillin and Oxacillin were 100%, resistance rate to Cefazolin,Cefuroxime, Cefotaxime,Ceftizoxime were higher, Clindamycin was about 53%; The sensitive rate to Sulfamethoxazole/Trimethoprim, Norfloxacin and Rifampicin were higher. No strain was found to be resistant to Vancomycin, Fusidic acid, Teicoplanin, Levofloxacin, Minocycline, Furadantin and Dalfopristin.Conclusion The proportion of separation of samples of infants were comparatively large. The sensitive rate to Vancomycin, Fusidic acid, Teicoplanin, Dalfopristin, Sulfamethoxazole/Trimethoprim, Furadantin,Rifampicin were high in our studying,they were may be suitable for MRSA induced the infection in children in the north areas of Guilin.更多还原