【摘要】 目的探讨尤瑞克林对不同结构性影像类型进展性脑梗死治疗90 d的疗效。方法 2007-03～2012-06按入院时不同结构性影像类型将进展性脑梗死分为大灶梗死、中灶梗死、小灶梗死及腔隙梗死4型,共277例,采用分层随机分组的方法将患者分为尤瑞克林组(治疗组)141例,对照组136例。两组基础用药均为疏血通6 ml+生理盐水250 ml静脉滴注;胞磷胆碱0.5 g+生理盐水250 ml静脉滴注;阿司匹林0.1 g口服,以上用药均为1次/d,连用4周。治疗组同时给予生理盐水100 ml+尤瑞克林0.15 PNAu(对硝基苯胺单位)静脉滴注,对照组同时给予生理盐水100 ml静脉滴注,1次/d,连用7～14 d,两组均在疗程结束当天及出院后90 d应用改良Rankin量表(mRS)进行疗效评定。结果治疗后90 d,两组患者mRS评分均继续减少,治疗组中的大、中、小灶梗死组mRS评分减少更为显著,均优于对照组(P<0.05)。结论尤瑞克林能促进进展性脑梗死患者远期神经功能的恢复,降低致残水平。更多还原

【Abstract】 Objective To investigate the 90 days follow-up result of mRS after the treatment of Urinary kallidinogenase in the patients with progressive cerebral infarction in different imageology styles.Methods Two hundred and seventy-seven patients with progressive cerebral infarction from March 2007 to June 2012 were divided into four subgroups according to different imageology styles:large infarct,middle infarct,small infarct and lacunar infarct.These patients were randomly divided into two groups:treatment group with urinary kallidinogenase(n=141) and control group(n=136).Two groups were administrated intravenous injection of Shuxuetong 6 ml in physiological saline 250 ml,Citicoline 0.5 g in physiological saline 250 ml and oral aspirin 0.1 g per day for 4 weeks.On the basis of above treatment,treatment group was administrated intravenous infusion of urinary kallidinogenase 0.15 PNAu in physiological saline 100 ml,control group was administrated physiological saline 100 ml per day for 7~14 days.The efficacy was evaluated by mRS(Modified Rankin Scale) at the end of treatment and 90 days after-discharge respectively.Results The resuts showed that 90 days affter-discharge,the scores of mRS in two groups decreased,especially in large infarct,middle infarct and small infarct subgroups.The treatment group was superior to control group in decrease of the scores of mRs(P<0.05).Conclusion Urinary kallidinogenase is effective to promote long-term neurofunctional recovery and step down mutilation of progressive cerebral infarction.更多还原