【摘要】 目的了解氟铃脲原药对大鼠的亚慢性毒性,求出最大无作用剂量。方法将80只SD大鼠随机分为4组,每组20只,分别给氟铃脲原药800、400、200、0 mg/(kg·d)灌胃染毒90 d,每周称量大鼠体重,90天后检测各项血生化指标,测定脏器重量并计算脏器系数,光学显微镜下对脏器进行病理学检查。结果氟铃脲原药大剂量组[800 mg/(kg·d)]、中剂量组[400 mg/(kg·d)]肝组织病理学检查可见形态改变,血清天冬氨酸转氨酶(AST)活力升高。小剂量组[200 mg/(kg·d)]各项指标与对照组比较未见异常。结论氟铃脲原药对大鼠有肝脏毒性,最大无作用剂量为200 mg/(kg·d)。更多还原

【Abstract】 [Objective]To study the subchronic toxicity of Hexaflumuron in rats and obtain no observed adverse effect level( NOAEL).[Methods]A total of 80 SD rats were randomly divided into four groups,with 20 in each group. The rats were gavaged hexaflumuron at dose of 800 mg /( kg·d),400 mg /( kg·d),200 mg /( kg·d),0 mg /( kg·d) for 90 days. Body weight was measured per week. Serum biochemical indicators were determined at the end of the study. Organ weight was measured and organ index was calculated. Pathological examination was performed on organs under an optical microscope.[Results]The results showed pathological changes of the liver were observed in the high dose[800 mg /( kg·d) ]group and medium dose[400 mg /( kg·d) ]group. Serum activity of aspartate aminotrans ferase( AST) increased in rats. No significant changes in indicators were found in the low dose group [200 mg /( kg·d) ].[Conclusion]The Hexaflumuron can induce liver harm,The NOAEL is 200 mg /( kg·d).更多还原