【摘要】 目的:对"浙八味"药材中9种有机氯农药残留量和铅(Pb)、镉(Cd)、铜(Cu)含量进行测定与分析,为其质量控制和安全用药提供可靠的依据。方法:农残分析以混合溶剂超声提取、浓硫酸磺化净化样品,HP-5弹性石英毛细管柱程序升温分离,微电子捕获检测器检测,峰面积外标法定量。重金属分析用灰化法处理样品,火焰原子吸收分光光度法进行测定。结果:延胡索、麦冬和杭白菊检出滴滴涕,含量分别为0.439、45.017及5.434 ng.g-1,杭白菊检出五氯硝基苯,含量为1.030 ng.g-1。其余药材均未检出有机氯农药残留。8种药材中铅的含量范围为0.8281～1.7473 mg.kg-1,镉的含量范围为0.1169～0.2950 mg.kg-1,铜的含量范围为2.5195～8.2864 mg.kg-1。结论:"浙八味"药材大部分未检出有机氯农药残留或含量较低,均在《药用植物及制剂进出口绿色行业标准》所规定的安全范围内。8种药材均检出一定量的有害重金属,但含量较低,符合《药用植物及制剂进出口绿色行业标准》的有关规定。更多还原

【Abstract】 Objective:The content of nine kinds of organochlorine pesticides and lead(Pb),cadmium(Cd)and copper(Cu)in eight famous herbal drugs in Zhejiang were determined.The analysis would supply the reference for the quality control and the safety.Method:Organochlorine pesticides:the samples were tracted with mixed solvent,then extracted by ultrasonic device and purified with sulfuric acid.Separtion was accomplished with heated HP-5 fused-silica capillary column with micro-electron capture detector.The external standard was used.Heavy metal:samples were digested with dry ash method and the Pb,Cd and Cu were determined by Flame Atomic Absorption Spectrophotometry.Results: dichlorodiphenyl trichloroethane(DDT)was detected of Corydalis yanhusuo W.T.Wang,Ophiopogon japonicus(Thunb.)Ker-Gawl.and Chrysanthemum morifolium Ramat.The contents of DDT were 0.439ng·g-1,45.017 ng·g-1 and 5.434 ng·g-1.pentachloronitrobenzene(PCNB)was detected of Chrysan-themum morifolium Ramat.The content of PCNB was 1.030 ng·g-1.Other samples did not have these nine organochlorine pesticides.The contents of lead,cadmium and copper were 0.8281~1.7473 mg·kg-1,0.1169~0.2950 mg·kg-1 and 2.5195~8.2864 mg·kg-1 respectively.Conclcusions:The contents of bexachlorocyclohexane(BHC),dichlorodiphenyl trichloroethane(DDT)and pentachloronitro-benzene(PCNB)in most medicinal materials of eight famous herbal drugs in Zhejiang had no discovered or had lower levels which were within the ermissible limits of Green Trade Standards of Importing and Exporting Medicinal Plants and Preparations.Heavy metals that detected in all samples were under the limits of the standards and accorded with the provision of The Professional Import and Export Standards for Medicinal Herbs and Preparations.更多还原