【摘要】 目的:研究小儿重型β地中海贫血的中医证候分布规律。方法:制定中医证候观察表,对61例重型β地中海贫血患儿进行中医证候调查,并建立数据库,运用聚类分析等统计学手段结合临床判定其证候分布。结果:聚类分析结果聚为四类,分别为肝肾阴虚证(占36.1%)、气血两虚证(占24.6%)、阴阳两虚证(占21.3%)、脾肾阳虚证(占18.0%)。肝肾阴虚证及气血两虚证的血红蛋白(Hb)水平均显著高于阴阳两虚证(P<0.05)。结论:在主要来自于广东省内的小儿重型β地中海贫血患者中,中医证候分布为肝肾阴虚证>气血两虚证>阴阳两虚证>脾肾阳虚证,研究为小儿重型β地中海贫血规范化辨证论治提供了一定依据。更多还原

【Abstract】 Objective: To explore the distribution regularity of TCM syndromes of severe β-thalassemia.Methods: Observation forms of TCM syndromes of thalassemia was made to investigate the TCM syndromes of 61 pediatric cases of severe β-thalassemia and database was established to determine distribution of TCM syndromes by cluster analysis and other methods.Results: Four syndrome patterns of severe β-thalassemia were: deficiency of liver-yin and kidney-yin(36.1%),deficiency of qi and blood(24.6%),deficiency of yin and yang(21.3%),and deficiency of spleen-yang and kidney-yang(18.0%).Hb values of the patients with deficiency of liver-yin and kidney-yin syndrome and with deficiency of qi and blood syndrome were both significantly higher than those of the patients with deficiency of yin and yang(P<0.05).Conclusion: The distribution of TCM syndromes pattern of severe β-thalassemia in Guangdong province is: deficiency of liver-yin and kidney-yin>deficiency of qi and blood >deficiency of yin and yang >deficiency of spleen-yang and kidney-yang.This study can offer some references for the normative treatment of children with severe β-thalassemia based on TCM syndromes differentiation.更多还原