【摘要】 目的:观察硒对桥本甲状腺炎(HT)患者甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)的影响。方法:选取TPOAb在100~600IU/ml之间,TGAb在200IU/ml到2000IU/ml之间的HT患者66例,随机分为硒治疗组与对照组,硒治疗组(n=46)服硒酵母片(100μg,2次/d)和左甲状腺素钠片(维持TSH至0.27~4.2μIU/ml)治疗;对照组(n=20)服左甲状腺素钠片(维持TSH至0.27~4.2μIU/ml)治疗,比较两组治疗3个月后TPOAb及TGAb水平的变化。结果:治疗3个月后两组TGAb水平与治疗前相比,差异无统计学意义(P>0.05)。治疗3个月后,两组TPOAb水平明显降低,但降低值差异无统计学意义(P<0.05)。结论:硒对桥本甲状腺炎患者轻度增高的TPOAb及TGAb水平无明显影响。更多还原

【Abstract】 Objective:To observe the effect of selenium on thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb)in patients with Hashimoto thyroiditis(HT).Method:66 patients with HT whose TPOAb levels were between 100 IU/ml and 600 IU/ml,TGAb levels were between 200 and 2000 IU/ml were randomized into selenium treatment group and control group.The selenium treatment group(n=46)received selenium yeast 200μg per day ,plus L-thyroxine to maintain TSH levels between 0.27-4.2 μIU/ml ;the control group received L-thyroxine to maintain TSH levels between 0.27-4.2μIU/ml.After 3 months compared the changes of TPOAb and TGAb levels in the two groups.Result:There were no significant changes of TGAb levels after 3 months of treatment compared with before treatment in the two groups( P >0.05).There were significant decrease of TPOAb levels after 3 months in the two groups,but the reduction had no significant difference between the two groups.Conclusion:Selenium has no significant effect on slightly increased TPOAb and TGAb levels in HT.更多还原