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迷迭香酸的提取分离及药理学新发现
New progress in the research of rosmarinic acid separation, purification and pharmacological actions
【摘要】 迷迭香酸是一种天然的水溶性多酚类化合物,具有抗炎、抗氧化、抗菌、抗病毒、免疫调节、抗血栓和抗血小板凝聚等作用,一直以来广泛用于食品和化妆品行业。近来,迷迭香酸众多新的药理活性被发现,随即在医药领域崭露头角,因此,有关迷迭香酸的提取分离也倍受关注。本文综述近几年来有关迷迭香酸的分离纯化进展和新发现的药理学活性,如抗辐射、抗诱变、保护脑组织和治疗过敏性疾病等,及其在食品、化妆品和医药领域中的应用现状。
【Abstract】 Rosmarinic acid is a naturally occurring water-soluble polyphenol compound commonly distributed in species of Boraginaceae and the subfamily Nepetoideae of Lamiaceae.It possesses a number of interesting biological activities,such as.anti-inflammatory,antioxidant,anti-bacterial,immunoregulatory and mesangial cell proliferation-inhibitory effects.As kinds of new biological effects having been discovered,rosmarinic acid has become a potential hot in pharmaceutical industry.Consequently,its isolation and purification had also attracted us.In order to offer more information for utilization of rosmarinic acid effectively,a brief review was given on the new progresses in the research of its isolation,purification,biological activities and industrial applications.
【Key words】 rosmarinic acid; medium pressure preparative liquid chromatography; resin; pharmacological action; application;
- 【文献出处】 中国新药杂志 ,Chinese Journal of New Drugs , 编辑部邮箱 ,2013年04期
- 【分类号】R284;R285
- 【被引频次】50
- 【下载频次】1767