【摘要】 微针给药是一种新型的经皮给药方式,可在皮肤上创造微米级的药物运输通道,增强皮肤对药物尤其是大分子药物的渗透性,且不会到达神经分布丰富的皮肤深层组织。生物可降解微针是以生物可降解材料为基质制作出的微针,除具有一般微针的优点,其具有的生物可降解特性解决了微针一旦断裂于皮肤内难以处理这一难题。因此生物可降解微针有望成为经皮给药的理想载体。本文对生物可降解微针的特点、制作方法、基质的选择、在经皮给药系统中的应用以及存在的问题等进行了概述。更多还原

【Abstract】 Microneedles are a new type of transdermal drug delivery.It can create a micron-level drug delivery channel on the skin and enhance the permeability of skin for drugs,especially macromolecular drugs,and it does not reach to the nerves in deep skin tissue.Because of using biodegradable materials as a substrate,biodegradable microneedle has the characteristics of biodegradable,self-degradation in the skin,which can solve the difficulty of microneedles broken into skin.As a new transdermal drug delivery technology,it might be an ideal vehicle for biological macromolecules,peptides,vaccines and other drugs.This article provided an overview of the characteristics of biodegradable microneedles,manufacture method,the matrix of choice,application,existing problems and so on.更多还原