【摘要】 [目的]探讨溃疡性结肠炎(UC)与5-羟色胺转运体启动区(5-HTTLPR)基因多态性的关系。[方法]聚合酶链反应技术检测30例UC患者(病例组)与30例健康对照组5-HTTLPR多态性的分布频率。[结果]病例组5-HTTLPR的S/S基因频率为50.0%,健康对照组S/S基因频率为33.3%,2组之间比较差异有统计学意义(P<0.05)。病例组5-HTTLPR的L/S、L/L的基因频率分别为40.0%、10.0%,健康对照组L/S、L/L的基因频率分别为43.3%、23.3%,2组之间比较,差异无统计学意义(P>0.05)。[结论]5-HTTLPR的S/S基因型可能与UC的发病有关。更多还原

【Abstract】 [Objective]To explore the association between ulcerative colitis(UC) and the polymorphisms of serotonin transporter(SERT) gene-linked polymorphic region(5-HTTLPR).[Methods]Polymerase chain reaction(PCR) was used to detect 5-HTTLPR polymorphism of SERT gene in 30 patients with UC and in 30 control subjects.[Results]The S/S genotype frequency of 5-HTTLPR alleles was significantly higher in UC patients than in controls(50.0% vs 33.3%;both P<0.05).The 5-HTTLPR genotypes frequencies showed that L/L was 10.0%,L/S was 40.0% in UC patients,and L/L23.4%,L/S 43.3% in control subjects,there was no difference between UC patients and controls subjects(P < 0.05).[Conclusion]5-HTTLPR L/L genotype may play an inportant role in the pathogenesis of ulcerative colitis.更多还原