【摘要】 目的探讨血管内皮生长因子(VEGF)和白介素-6(IL-6)在2型糖尿病(T2DM)患者发生发展中的作用。方法采用ELISA技术检测50例2型糖尿病患者和50例健康对照者血清VEGF、IL-6水平。结果与正常对照组相比,T2DM患者血清VEGF水平显著增高(P<0.001),合并肾病较未合并肾病患者血清VEGF水平显著增高(P<0.001);IL-6水平在两组间无显著性差异;受检者空腹血糖水平与血清VEGF水平之间呈高度正相关(P<0.01),与IL-6水平无明显相关关系。结论 T2DM患者中血清VEGF生成增高,尤以并发糖尿病肾病患者为甚,提示高水平的VEGF可能在T2DM及其肾病并发症的发生、发展过程中起着一定作用。更多还原

【Abstract】 【Objective】To explore the role of vascular endothelial growth factor and interleukin-6 in the development of type 2 diabetes mellitus(T2DM).【Methods】Serum vascular endothelial growth factor(VEGF) and interleukin-6(IL-6) were detected by enzyme-linked immunosorbent assay(ELISA) in 50 T2DM patients and 50 normal persons.【Results】Serum VEGF of patients with T2DM were significantly higher than of the controls(P <0.001),there was no difference in serum IL-6 levels between two groups.The VEGF level was significantly higher in patients with diabetic nephropathy than in patients without nephropathy(P <0.001).Fasting blood glucose was positively correlated with VEGF(P <0.01).【Conclusions】VEGF may play an important role in the occurrence and development of the type 2 diabetes mellitus and diabetic complications.更多还原