【摘要】 目的探讨门冬氨酸特异半胱氨酸蛋白酶-1(Caspase-1)和白细胞介素-1β(IL-1β)在2型糖尿病发生过程中的作用。方法 MKR成模后小鼠随机分为对照组、格列本脲组和实验组,以免疫组化法检测各组Caspase-1及IL-1β的表达。结果各组Caspase-1及IL-1β表达分别为(28.38±13.11)v(s13.41±2.50)、(20.32±3.34)v(s 10.64±2.92)、(15.06±6.67)v(s 8.41±2.27),P<0.01,差异有显著性。结论 Caspase-1和IL-1β在2型糖尿病发生过程中起着重要作用,为开发治疗2型糖尿病的药物和方法提供了新思路。更多还原

【Abstract】 【Objective】 To study the role of Caspase-1 and IL-1β in the course of type 2 diabetes mellitus(T2DM).【Methods】 MKR mice were randomly divided into control group,glibenclamide group and treatment group.The amount of Caspase-1 and IL-1β were tested by immunohistochemistry.【Results】 The amount of Caspase-1 and IL-1β of three groups were(28.38±13.11)vs(13.41±2.50),(20.32±3.34)vs(10.64±2.92),(15.06±6.67)vs(8.41±2.27) respectively.There was great difference among three groups(P <0.01).【Conclusion】 Caspase-1 and IL-1β play an important role in the course of T2DM.It provides a new idea to the treatment of T2DM.更多还原