【摘要】 目的:分析人乳头瘤病毒(HPV)与鳞状上皮细胞癌抗原(SCCA)、癌胚抗原(CEA)等多种肿瘤标志物在不同宫颈疾病中的临床价值及相关性分析。方法:采用基因芯片导流杂交技术检测155例宫颈疾病患者脱落细胞标本中的HPV亚型,取同期20例健康体检妇女为正常对照组;同时采用化学发光法检测各组血清多种肿瘤标志物水平。结果:高危型HPV感染在多种宫颈疾病中占有较大的比重;CYFRA21-1在不同宫颈病变的HPV感染患者中均较正常对照组升高(P均<0.05);ROC曲线显示,相对于其它几个肿瘤标志物,SCCA有更好的敏感性和特异性。结论:高危型HPV感染在宫颈癌中的比率明显高于宫颈不典型增生及慢性宫颈炎(62.50%vs 35.98%及30.00%);相对于CEA、CA125、CA19-9,SCCA有更好的敏感性和特异性,可作为宫颈癌辅助检测的指标。更多还原

【Abstract】 Objective:To analyze the clinical value of HPV typing,squamous cell carcinoma antigen(SCCA),carcinoembryonic antigen(CEA) and other tumor markers in different cervical diseases,and the correlation with a variety of cervical diseases.Methods: Flow-through hybridization and gene chip was used to detect the HPV subtype in exfoliated cells of 155 patients with cervical disease,and the levels of serum CA125,CA19-9,CYFRA 21-1,SCCA and CEA were measured by chemiluminescence assay.At the same time,twenty normal healthy women were selected as the control group for comparative analysis.Results: High-risk HPV infection occupied a large proportion in cervical diseases.The serum CYFRA21-1 level was significantly higher in all cervical diseases than that in healthy controls(P<0.05).ROC curves showed SCCA was more sensitive and specific in the diagnosis of uterine cervix cancer.Conclusion: High-risk HPV infection was more frequent in cervical cancer(62.50%) compared to cervical dysplasia(35.98%) and chronic cervicitis(30.00%).SCCA had better sensitivity and specificity than CEA,CA125 and CA19-9,so it can be used for supplementary diagnosis of cervical cancer.更多还原