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尿酸水平及高尿酸血症的民族差异性研究

Analysis of uric acid level and the prevalence of hyperuricemia among different nationnalities

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【作者】 玛伊娜·卡哈尔张伟张蓓孙玉萍

【Author】 MAYINA.Kahaer1,ZHANG Wei2,ZHANG Bei1,SUN Yu-ping1*(1.Xinjiang Medical University,Urumchi 830011,China;2.Department of Clinical Laboratory,The First Affiliated Hospital of Xinjiang Medical University,Urumchi 830011,China)

【机构】 新疆医科大学基础医学院新疆医科大学第一附属医院检验科

【摘要】 目的:分析尿酸水平及高尿酸血症的民族差异性。方法:采用随机抽样的方法在乌鲁木齐市健康体检人群中选择维吾尔族和汉族作为研究对象,检测其尿酸水平并分析民族之间的差异性。结果:汉族尿酸水平和高尿酸血症检出率均高于维吾尔族,男性尿酸水平和高尿酸血症检出率也高于女性,且发病年龄早于女性。尿酸值和高尿酸血症有随年龄增长而增长的趋势,尤其是女性在50岁以后有明显的增高。结论:新疆汉族和维吾尔族尿酸水平和高尿酸血症的发生存在民族差异性,在两个民族生活方式和饮食习惯逐渐趋向一致的情况下,仍然表现出的民族差异,可能与两个民族的遗传背景有关,因此了解不同民族正常人群的尿酸水平和高尿酸血症发病率对于探讨该疾病的发病机制具有重要的意义。

【Abstract】 Objective:To analyze the serum uric acid level and hyperuricemia in Han and Uyghur people,so as to find the nationality difference.Methods: The blood samples were collected in hospital and analyzed for the uric acid level and prevalence of hyperuricemia in two nationalities.Results: The uric acid level and prevalence of hyperuricemia in Han was higher than Uyghur(P<0.05),higher in men than women in two nationalities(P<0.05).With the age growing,the uric acid level and prevalence of hyperuricemia increased(P<0.05),especially more obvious increase in women above 50 years old.Conclusion: The uric acid level and prevalence of hyperuricemia showed difference between two nationalities and genders.Now the lifestyle and eating habits were becoming same in Han and Uyghur,but differences were remain between two nationalities,it may be related to the genetic background of the two peoples.Therefore,understanding the uric acid levels and the detection rate of hyperuricemia in normal people of two nationalities have great significance for studying the pathogenesis of this disease.

【基金】 国家重点基础研究发展计划(973计划)资助(2012CB722403);国家自然科学基金项目资助(81160115);新疆维吾尔自治区自然科学基金项目资助(200821133)
  • 【文献出处】 中国卫生检验杂志 ,Chinese Journal of Health Laboratory Technology , 编辑部邮箱 ,2013年04期
  • 【分类号】R589.7
  • 【被引频次】6
  • 【下载频次】82
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