【摘要】 目的:探讨慢性乙型肝炎合并戊型肝炎病毒感染患者的免疫功能情况。方法:对66例单纯乙型肝炎病毒感染患者和44例重叠感染者的免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)及淋巴细胞亚群进行检测分析。结果:重叠感染组免疫球蛋白略高于单纯感染组,其中IgG水平差别有统计学意义(t=1.94,P<0.05)、T淋巴细胞略低于单纯感染组,CD8+和CD4/CD8+差别有统计学意义(t分别为2.53、2.56,P<0.05),而CD16+/CD56+(NK)细胞数高于单纯感染组(t=3.01,P<0.05)。结论:重叠感染组患者的体液免疫和细胞免疫的激活过度或不足可能是导致其重症化的原因。更多还原

【Abstract】 Objective:To investigate the immune status in patients with chronic hepatitis B and hepatitis E.Methods: The immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG) and lymphocyte subsets were detected in 66 cases with hepatitis B virus infection alone and 44 cases of patients with superinfection.Results: The immunoglobulin in group of overlapping infection was slightly higher than the group of simple infection.While IgG was statistically significant(t=1.94,P<0.05),T lymphocytes in group of overlapping infection was slightly lower than the group of simple infection,while CD8 + and CD4/CD8 + was statistically significant(t=2.53,2.56,P<0.05),and CD16+/CD56+(NK) cells in group of overlapping infection was slightly higher than the group of simple infection(t=3.01,P<0.05).Conclusion: The excessive or insufficient humoral and cellular immune activation in group of overlapping infection may be the reasons leading to severe cases.更多还原