【摘要】 目的:探讨慢性肾功能衰竭(CRF)患者血清高分子量脂联素多聚体(HMW-APN)水平及临床意义。方法:ELISA方法测定55例非血液透析的CRF患者(A组),58例血液透析的CRF患者(B组)和50例健康人(C组)血清HMW-APN、总APN水平、肾功能和血脂,并测定颈动脉内膜-中膜厚度(IMT)及粥样斑块发生率,分析各指标间的相关性。结果:1.A和B组血清HMW-APN、总APN水平等均高于C组,B组IMT厚度和粥样斑块发生率均高于A组(P<0.05),B组血清HMW-APN水平低于A组(P<0.05);2.HMW-APN水平与甘油三酯(TG)呈负相关(r=-0.312,P<0.05),与尿素氮(BUN)、肌酐(Cr)呈正相关(r=0.713、0.512,P<0.05);总APN水平与肌酐(Cr)呈正相关(r=0.681,P<0.05)。结论:同时检测HMW-APN和总APN的水平是观察CRF的一个较好的指标。更多还原

【Abstract】 Objective:To investigate the level and clinical significance of serum High-Molecular-Weight complex of adiponectin(HMW-APN) in chronic renal failure(CRF) patients.Methods: The levels of HMW-APN and total APN,renal function and blood lipid in 55 non-hemodialysis CRF patients(Group A),58 hemodialysis CRF patients(Group B) and 50 healthy people(Group C) were measured by ELISA,and the carotid intima-media thickness(IMT) and plaque prevalence were determined,then the correlation among different indicators were analyzed.Results: 1.Serum HMW-APN,total APN levels of Group A and Group B were significantly higher than those of Group C(P<0.05),serum HMW-APN levels of Group B were significantly lower than those of Group A,while IMT and prevalence of carotid artery plaque of Group B were higher than those of Group A(P<0.05).2.Serum HMW-APN levels were negatively correlated to TG(r=-0.312,P<0.05) and positively relatived to BUN,Cr(r=0.713,0.512,P<0.05);Serum total APN levels were positively relatived to Cr(r=0.681,P<0.05).Conclusion: Simultaneous detection of HMW-APN and total APN will be a very good indicator to observe CRF.更多还原