【摘要】 目的:探讨血清胱抑素C(CyC)联合肌酐(Scr)、尿素氮(Bun)检测在肾功能损害诊断中的临床意义。方法:收集96例确诊为肾脏损害的住院患者及52例健康体检者,分为健康体检组、继发性肾病组(包括高血压肾病和糖尿病肾病患者)、尿毒症组,分析其血清CyC、Scr、Bun值,采用t检验进行比较分析。结果:CyC、Scr、Bun的异常率分别为62.16%、52.70%、54.73%,其中CyC的异常率高于Scr和Bun;尿毒症组中CyC、Scr、Bun渐进显著性(双侧)分别为0.806、0.952、0.866,继发性肾病组为0.721、0.746、0.687,健康体检组为0.762、0.852、0.726。结论:胱抑素C是一个对肾功能损害敏感且诊断价值较大的指标,但其特异性较低,可与特异性较高的肌酐、尿素氮联合检测以提高检测肾功能损害程度的灵敏度和特异性。更多还原

【Abstract】 Objective:To discuss the value of joint detection of serum Cystatinc C,creatinine and urea nitrogen for renal disfunction indexes.Methods: Ninety-six hospital inpatients with renal disfunction and 52 healthy subjects were collected and divided into healthy control group,secondary nephropathy group and uremia group,and the levels of serum CyC,Scr,Bun in these groups were analyzed using t test.Results: The abnormal rate of CyC and Scr,Bun were 62.16%,52.70%,54.73%.The abnormal rate of CyC was higher than that of Scr and Bun;The progressive significances(bilateral) of CyC,Scr and Bun in uremia group were 0.806,0.952 and 0.866 respectively,in secondary nephropathy group were 0.721,0.746 and 0.687 respectively,in healthy control group were 0.762,0.852 and 0.726 respectively.Conclusion: CyC is a sensitive index for renal dysfunction with higher diagnostic value,but because of the low specificity,it has to combine with the creatinine and urea nitrogen to improve the sensitivity and specificity of renal dysfunction detection.更多还原